Palo Azul vs. Sciatic Nerve Pain

woman with sciatic nerve pain

Medical studies show 2 reasons why Palo Azul is essential for relieving sciatic nerve pain!

One of the lesser known benefits of Palo Azul is that it can improve sciatic nerve health. The main reason for this is that sciatic nerve pain is commonly caused by an accumulation of uric acid in the blood, and Palo Azul is an active reducer of uric acid levels.

Inflammation is another common cause of sciatic nerve pain and many studies have proven Palo Azul’s powerful anti-inflammatory activity. For these 2 reasons, Palo Azul has been traditionally used to cure sciatic nerve pain for centuries!

Here's a list of some of the most anti-inflammatory foods: vegetables, fruits, nuts, seeds, fatty fish, olive oil, turmuric, cocoa and teas such as palo azul

palo azul and antiinflammatory foods

Uric Acid Reducer

One study mentions that “the plant (palo azul) has been used in traditional treatments of nephrolithiasis or urolithiasis [2], lumbalgia, arthritis, rheumatism, sciatica, and as blood depurative because it eliminates uric acid, of which application the palo azul derives its diuretic and antirheumatic fame.”

Another study found that uric acid indices were significantly higher in the group of diabetic mice that did not receive the blue stick extracts compared to the control group.

This same study concluded the following:

Groups treated with 25, 50, and 100 mg/kg of the dihydrochalcone (palo azul extract) showed a significantly decreased (p < 0.05) uric acid.”


Anti-inflammatory

Results from 6 different studies concluded in their results that Palo Azul induced a significant inhibition of inflammation and/or showed anti-inflammatory activity.

Moreover, several studies show that “methanol, ethanol, or flavonoids in Palo Azul act as anti-inflammatory agents.”

omega 3 antiinflammatory

One medical study concluded the following: The inhibition (of inflammation) leads to a reduction in pain behavior and inflammation following chronic constriction injury (CCI) of the sciatic nerve.

Another medical article mentions that “any cause of irritation or inflammation of the sciatic nerve can produce the symptoms of sciatica.”

palo azul joint health

Hundreds of studies have shown that Palo Azul and its flavonoids are powerful anti-inflammatories and because of this property, their ability to calm joint pain has been demonstrated.


Flavonoids

But that's not all!...In addition to the palo azul's ability to inhibit inflammation and reduce uric acid levels, it also contains some of the healthiest compounds in the world!

palo azul flavonoids

You can learn all about Flavonoids here, but for now just know that there are hundreds of studies that have shown that they have anti-inflammatory, anti-oxidant, anti-aging properties, etc.

In fact, one study found that flavonoids (found in vegetables, fruits and teas like palo azul) “have the most potential of dietary components for promotion of bone health beyond calcium and vitamin D.”

palo azul strengthens joint health

This finding is supported by population studies which have shown “flavonoid consumption to have a stronger association with bone than general fruit and vegetable consumption.”

These are some of the MOST antioxidant-rich foods: apples, pears, onions, strawberries, blueberries, celery, peppers, and teas such as palo azul

applepearsonionsstrawberries and blueberriescelerypalo azul tea



Antinociceptive

You thought that was it didn’t you ;)?

Several studies have shown that palo azul has antinociceptive properties. What does this mean? Antinociceptives block the detection of a painful or harmful stimulus by sensory neurons.

palo azul antinociceptive

In other words... they inhibit the sensation of pain by blocking signals from neurons.

Popular examples of antinociceptives include general anesthesia and morphine.

palo azul antiniociceptive pain

One study mentioned that palo azul “decreased the serum levels of pro-inflammatory cytokines and showed antinociceptive activity. These findings support the use of Eysenhardtia polystachya in Mexican folk medicine for treating rheumatoid arthritis and pain management.


Here's an interesting finding!

Another study found that palo azul “showed antinociceptive and antidiarrheal effects with similar potency compared to standard drugs.”


* Although we do not recommend replacing standard medications, these findings establish the importance of having a diet full of natural medicines with potent health benefits.

palo azul and fruits with flavonoids

For these reasons Palo Azul has been used traditionally for centuries to treat conditions such as arthritis, rheumatism, lumbago, gout and sciatica.

Below, we have summarized the key points of ALL the medical studies we have analyzed and also cited all the scientific literature.

Enjoy! :)

...And don't forget to help your friends and family by sharing MagickTea Palo Azul with them!

book with palo azul benefits and studies

Key findings from medical studies

• One article states that "the action of this natural medicine decreases uric acid levels in the blood, which is the main factor causing discomfort for these conditions (sciatica).”

• “Medications used in the treatment of sciatica include pain relievers, muscle relaxants, anti-inflammatories, and antidepressants.”

• “We evaluated the anti-arthritic and antinociceptive properties of an ethanolic extract of E. polystachya (EE) bark and its rich-flavonoids fractions in murine models. Many plant constituents, including flavonoids, have proven effective against arthritis by reducing cartilage degradation, diminishing leukocyte infiltration in the synovial space, decreasing serum cytokine levels, and other mechanisms (9).“

• “Our findings support the use of Eysenhardtia polystachya bark for the treatment of rheumatoid arthritis and pain management.”

• “The results here presented corroborate the folk medicinal use of Eysenhardtia polystachya in the treatment of infections, diarrhea, inflammation, and pain.”

This is why you should be eating vegetables, fruits and drinking Palo Azul every day!
Now you see why we call it MagickTea?
Try Palo Azul and experience its radiant taste and enjoy all its magical benefits!

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Medical Studies

* Palo Azul is commonly referred to by its scientific name: Eysenhardtia polystachya / E. polystachya / E.P - Cyclolepis genistoides / C. genistoides - kidney wood - palo dulce


(2010) Transgenic inhibition of glial NF-kappa B reduces pain behavior and inflammation after peripheral nerve injury

We utilized a transgenic mouse model (GFAP-IκBα-dn) where the classical NF-κB pathway is inactivated by overexpression of a dominant negative (dn) form of the inhibitor of kappa B (IκBα) in glial fibrillary acidic protein (GFAP)-expressing cells, which include astrocytes, Schwann cells, and satellite cells of the dorsal root ganglion (DRG) and sought to determine whether glial NF-κB inhibition leads to a reduction in pain behavior and inflammation following chronic constriction injury (CCI) of the sciatic nerve.

We can therefore conclude that transgenic inhibition of NF-κB in GFAP-expressing glial cells attenuated pain and inflammation after peripheral nerve injury. These findings suggest that targeting the inflammatory response in Schwann cells and satellite cells may be important in treating neuropathic pain.


(2019) Sciatica Nerve Pain

While sciatica is most commonly a result of a lumbar disc herniation directly pressing on the nerve, any cause of irritation or inflammation of the sciatic nerve can produce the symptoms of sciatica. This irritation of nerves as a result of an abnormal intervertebral disc is referred to as radiculopathy.

Medications used in the treatment of sciatica include pain relievers, muscle relaxants, anti-inflammatories, and antidepressants.


The duration of sciatica is critically dependent on its cause. A herniated disc, back sprain, shingles, and degenerative lumbar spine can all cause temporary forms of sciatica, lasting from days to weeks. Each can also cause chronic sciatica. Sometimes degeneration of the lumbar spine and discs can cause chronic sciatica that persists unless a surgical intervention is performed.


Keys to the management of acute sciatica include relief of pain and relaxing associated muscle spasms. Home remedies include heat and cold pack topical administration, over-the-counter pain medications such as acetaminophen (Tylenol), non-steroidal anti-inflammatory drugs like naproxen (Aleve), ibuprofen (Advil, Motrin), and aspirin, and physical therapy that incorporates gradual exercises and stretching. Exercises and stretching can sometimes best be guided by physical therapists.



(2008) Development of a capillary electrophoresis method for the characterization of “palo azul” (Eysenhardtia polystachya)

The plant has been used in traditional treatments of nephrolithiasis or urolithiasis [2], lumbalgia, arthritis, rheumatism, sciatica, and as blood depurative because it eliminates uric acid, of which application the palo azul derives its diuretic and antirheumatic fame. For inges- tion purposes, the wood chips are brought to boil in water to produce a golden-colored liquor having a light blue fluorescence, from which the sick can take two or three cups a day [3].

Among the E. polystachya components, there can be found polyphenol compounds, tannins, or flavonoid compounds [5, 6], which are a variable and complex mix- ture of bitter, astringent chemicals, although in general these are esters from one kind of sugar having a variable number of phenol acids [7].


(Winter 2018) The Ethanolic Extract of Eysenhardtia polystachya (Ort.) Sarg. Bark and Its Fractions Delay the Progression of Rheumatoid Arthritis and Show Antinociceptive Activity in Murine Models

Eysenhardtia polystachya is widely used in folk medicine as an anti-rheumatic and analgesic agent, but no systematic study of its effects on several markers associated with rheumatoid arthritis and its ethnomedical use as analgesic agent has been performed. We evaluated the anti-arthritic and antinociceptive properties of an ethanolic extract of E. polystachya (EE) bark and its rich-flavonoids fractions in murine models. Many plant constituents, including flavonoids, have proven effective against arthritis by reducing cartilage degradation, diminishing leukocyte infiltration in the synovial space, decreasing serum cytokine levels, and other mechanisms (9). Phytochemical studies indicate that E. polystachya contains polyphenols, and previous chemical examination of this species led to the isolation and structural elucidation of several flavonoids (11, 12). The methanol-water extract showed antidiabetic and anti-hyperlipidemic activities, an ability to reduce the formation of advanced glycation end products, and an antioxidant capacity in-vitro (12).


Conclusion: EE and its rich-flavonoids fractions inhibited secondary inflammatory reactions, diminished the specific histopathological alterations in the joint capsule and reduced the serum concentrations of the pro-inflammatory cytokines IL-6, TNF-α, and GM-CSF in arthritic rats. EE also reduced the number of writhes produced by acetic acid and increased the response time on the hot plate for mice. Our findings support the use of Eysenhardtia polystachya bark for the treatment of rheumatoid arthritis and pain management.

In conclusion, the ethanolic extract of Eysenhardtia polystachya bark and its rich-flavonoids fractions inhibited secondary inflammatory reactions in arthritic rats and delayed histopathological alterations of joint capsules. Eysenhardtia polystachya also decreased the serum levels of pro-inflammatory cytokines IL-6, TNF-α, and GM-CSF and showed antinociceptive activity at the peripheral and central levels, which suggests that this plant has an effect on the cellular immune response. These findings support the use of Eysenhardtia polystachya in Mexican folk medicine for treating rheumatoid arthritis and pain management.


(1986) Increased norepinephrine and uric acid levels in the spinal cord of arthritic rats

The norepinephrine and uric acid levels in the spinal cord were higher in arthritic rats than in normal rats. In addition the rate of disappearance of the amine was increased in the dorsal part of the cord in arthritic rats. These results agree with previous reports suggesting an activating effect of nociceptive stimuli on descending noradrenergic systems. They also indicate that studies on purine metabolism in the CNS in inflammatory and/or pain processes will be of interest.


(2008) Development of a capillary electrophoresis method for the characterization of “palo azul” (Eysenhardtia polystachya)

The plant has been used in traditional treatments of nephrolithiasis or urolithiasis [2], lumbalgia, arthritis, rheumatism, sciatica, and as blood depurative because it eliminates uric acid, of which application the palo azul derives its diuretic and antirheumatic fame. For inges- tion purposes, the wood chips are brought to boil in water to produce a golden-colored liquor having a light blue fluorescence, from which the sick can take two or three cups a day [3].


Among the E. polystachya components, there can be found polyphenol compounds, tannins, or flavonoid compounds [5, 6], which are a variable and complex mix- ture of bitter, astringent chemicals, although in general these are esters from one kind of sugar having a variable number of phenol acids [7].





(Feb 29, 2015) Evolution of anti-inflammatory activity of the bark of Eysenhardtia polystachia in experimental animal models

Our data indicate that PAM exhibited significant anti-inflammatory activity in all the trials of paw and ear edema induced exhibiting also anti-arthritic activity. PAM could also markedly inhibit production of pro inflammatory cytokines, especially TNF(alpha), IL-1(beta), PGE(2) and LTB(4). These effects resulted in an attenuation of the inflammatory cytokines and ultimately suppression of the edema. The extras also inhibited lipoxygenase and xanthine-oxidase. It was seen that PAM is effective on chronic inflammation and acute inflammation.

The methanol extract (PAM) exhibited significant (p<0.05) anti-inflammatory activity in all assays, instead hexane and chloroform extracts showed no anti-inflammatory activity.

PAM possesses significantly dose-related anti arthritic activity in M. tuberculosis-induced adjacent arthritis test in rat, which is considered close to simulating human rheumatoid arthritis.

The results of this study demonstrated that methanol extract of the bark of E.poystachya acts as an anti-inflammatory agent. It also can be a good source of effective crude inhibitors for XO and LOX. The finding presented in this study are encouraging an substantiate the search for newer pharmacophores in palo azul behind the anti-inflammatory effect.



(May 25, 2011) Anti-inflammatory properties from isolated compounds of Cyclolepis genistoides

Phytochemical studies of the aqueous extract of C. genistoides showed the presence of saponins, flavonoids, tannins, and anthraquinones. Instead, oleanolic acid (1) and the sesquiterpene lactone deacylcynaropicrin (2), which have been previously reported in this plant (De Heluani et. al., 1997), were isolated from the ethyl acetate extract. Compound 1 exhibited significant activity at 1, 3, 5, and 7 h, while compound 2 showed significant inhibition at 3 and 5 h.


Conclusions: From the results obtained in this work, we can conclude that the intraperitoneal administration of both isolated compounds from C. genistoides showed a significant inhibition of the carrageenan-induced inflammation at doses of 75 and 100 mg/kg, while the dose of 40 mg/kg did not produce a significant anti-inflammatory effect. Considering that compounds 1 and 2 were isolated from aerial parts of C. genistoides, these results give support to the use of this plant as an anti-inflammatory in traditional medicine.





(Oct, 2018) Pharmacological and toxicological study of a chemical-standardized ethanol extract of the branches and leaves from Eysenhardtia polystachya (Ortega) Sarg. (Fabaceae)

Eysenhardtia polystachya is used for the empirical treatment of cancer, infections, diarrhea, inflammation, and pain. This study identified, using GC-MS, the main chemical components in an ethanol extract of E. polystachya branches and leaves (EPE) and tested its cytotoxic, antimicrobial, anti-diarrheal, anti-inflammatory, and antinociceptive effects.

Conclusion: EPE exerted in vitro anti-inflammatory effects, mainly, by the decrease in the production of H2O2 (IC50 = 43.9 ± 3.8 µg/ml), and IL-6 (73.3 ± 6.9 µg/ml). EPE (ED50 =7.5 ± 0.9 mg/kg) and D-pinitol (ED50 = 0.1 ± 0.03 mg/kg) showed antidiarrheal activity, and antinociceptive effects in the acetic acid test with ED50 = 117 ± 14.5 mg/kg for EPE and 33 ± 3.2 mg/kg for D-pinitol. EPE showed also antinociceptive activity in the phase 2 of the formalin test (ED50 = 48.9 ± 3.9 mg/kg), without inducing hypnotic effects or altering the locomotor activity in mice. The results here presented corroborate the folk medicinal use of Eysenhardtia polystachya in the treatment of infections, diarrhea, inflammation, and pain. D-pinitol, the main metabolite of EPE, showed antinociceptive and antidiarrheal effects with similar potency compared to standard drugs.

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