Palo Azul vs Diabetes
Medical studies found that Palo Azul can improve your insulin sensitivity and reduce your glucose levels
What makes palo azul an antidiabetic?
We were certainly surprised to find all this research that suggested that this magical tea can potentially ameliorate diabetes! This plant has so many powerful and incredible benefits that we truly mean it when we say it is "The key for health" and that it's magic!
Various studies have found that extracts from palo azul “significantly reduced blood glucose levels” and showed “good anti-diabetic activity.”
In fact, 3 different studies have found that Palo Azul can improve insulin sensitivity, insulin secretion, glucose metabolism and/or increase muscle mass.
One study in particular concluded the following: “The results indicate that EP (Palo Azul) has good antidiabetic activity and therefore could be used to prevent the development of diabetes.”
In addition, it is well documented that oxidative stress can cause cancer, diabetes, cardiovascular disease, and aging. Therefore, antioxidants such as Palo Azul can “interfere with radical-producing systems and increase the function of endogenous antioxidants, protecting the cells from damage by these free radicals.”
What is oxidative stress?
Oxidative stress is an imbalance between free radicals and antioxidants in the body.
¿What are free radicals?
Free radicals are atoms with a single valence electron that cause damage to the body associated with diabetes, cancer, aging, atherosclerosis, Parkinson's, Alzheimer's and many other diseases.
This happens because electrons like to be in pairs... and for this reason, free radicals look for "free" electrons in the body. This causes damage to cells, proteins, DNA and these damaged molecules can mutate, grow tumors, and damage the DNA code. Eventually, this cellular damage causes new cells to grow with defects and it will lead to aging and degenerative diseases.
Flavonoids vs. Diabetes
On top of this...palo azul also contains flavonoids and “numerous epidemiological studies show an inverse correlation between dietary flavonoid consumption and chronic degenerative diseases, such as cardiovascular diseases, diabetes, osteoporosis, neurodegenerative diseases, and cancers.”
These are the MOST flavonoid-rich foods: apples, pears, onions, strawberries, blueberries, celery, peppers, and teas such as palo azul
Oxidative foods: foods that are heavily processed and have high fructose content, trans fats and refined carbs
Results from another study concluded that flavonoids in tea “may lower the risk of type 2 diabetes and cardiovascular diseases” and they even have a “beneficial effect on LDL-cholesterol and insulin sensitivity.”
Moreover, in a large cohort of women, a clinical trial has shown that "flavonoids are protective against type 2 diabetes.”
Finally, one study concluded the following:
“In conclusion, palo azul may increase muscle mass in the body and improve insulin resistance conditions.”
This is why you should eat vegetables, fruits, and drink palo tea azul every day!
Below, we have summarized the key findings of ALL the medical studies we have analyzed and also cited all the scientific literature.
...And don't forget to help your friends and family by sharing MagickTea Palo Azul with them!
Key findings from medical studies
• Several medical studies found that extracts from Palo Azul "significantly decreased blood glucose levels" and showed "good anti-diabetic activity.”
• “Palo Azul increased the expression of insulin-sensitizing adipokine, adiponectin, which is a direct target of PPARγ.”
“In conclusion, palo azul may increase muscle mass in the body and improve insulin resistance conditions by facilitating the formation of myotubes by promoting myocyte differentiation.”
• “Chalcones, flavonoids, and dihydrochalcones in palo azul “promote pancreatic β-cell survival, insulin secretion-enhanced hyperglycemia, and hyperlipidemia in glucose-induced diabetic zebrafish.” Finally, the researchers concluded that “these findings suggest that EP/AgNPs could be used as therapeutic nanoparticles to prevent the development of diabetes.”
“The oxidative stress may lead to cellular damage which is related to various health ailments such as diabetes, cancer, CVD, neurodegenerative disorders and ageing. Antioxidants interfere with radical-producing systems and increase the function of endogenous antioxidants, protecting the cells from damage by these free radicals.”
• “In addition, flavonoids have a role in the treatment of diabetes by virtue of their ability to protect against hyperglycemic and alloxan-induced oxidative stress in experimental animal models.”
* Palo Azul is commonly referred to by its scientific name: Eysenhardtia polystachya / E. polystachya / E.P - Cyclolepis genistoides / C. genistoides - kidney wood - palo dulce
The aim was to explore the efficacy of extract of Eysenhardtia polystachya-loaded silver nanoparticles (EP/AgNPs) on pancreatic β cells, INS-1 cells, and zebrafish as a valuable model for the study of diabetes mellitus. EP/AgNPs promote pancreatic β-cell survival, insulin secretion, enhanced hyperglycemia, and hyperlipidemia in glucose-induced diabetic zebrafish. EP/AgNPs also showed protection of the pancreatic β-cell line INS-1 against hydrogen peroxide-induced oxidative injury.
The tree Eysenhardtia polystachya (Ortega) Sarg, which belongs to the family Leguminosae, is known as “palo azul” and has been widely used as an antirheumatic and in the treatment of nephrolithiasis and bladder disorders that occur in diabetes.27 Phytochemical studies indicate that E. polystachya contains polyphenols.28 In another study, isoflavans displayed the moderate cytotoxic activity against KB cell lines.29 A methanol–water extract of the bark of E. polystachya showed antioxidant potential, hypoglycemic effects, and inhibition of the formation of advanced glycation end products (AGEs).30 The effect of flavonoids isolated from the bark of E. polystachya on oxidative stress in STZ-induced diabetes mellitus in mice was also examined.31 In other research, we determined that dihydrochalcones inhibit the formation of AGEs.32 The aim of the present study was to evaluate the effects of E. polystachya-loaded silver nanoparticles (EP/AgNPs) on glucose-induced diabetic zebrafish and peroxide-induced pancreatic INS-1 cell damage.
Treatment with EP/AgNPs alone or in the presence of H2O2 could ameliorate insulin sensitivity and glucose metabolism (Figure 6). EP/AgNPs promote pancreatic β-cell survival, insulin secretion-enhanced hyperglycemia, and hypolipidemia. These results confirming the effectiveness of nanoparticles in ameliorating hyperglycemia.
EP/AgNP treatment may provide beneficial effects on the function of insulin secretion through its protective effect on pancreatic β cells.48 In addition, a zebrafish model was used to confirm the antidiabetic efficacy of EP/AgNPs on experimental diabetic animals.
The findings demonstrated that diabetic fish had higher serum insulin concentrations than control zebrafish, suggesting pancreatic β-cell damage in this group, while EP/AgNPs at a dose of 100 µg/mL resulted in decreased plasma insulin levels (by 54%) compared with the glucose-induced diabetic fish group, which was similar to normoglycemic control zebrafish (Figure 8B). The results confirm the ability of EP/AgNPs to ameliorate cell viability and insulin secretion in zebrafish under high glucose concentrations. In this study, the treatments of zebrafish glucose-induced diabetes with EP/AgNPs were consistent with those reported in previous studies, confirming the effectiveness of nanoparticles in ameliorating hyperglycemia.
Conclusion: The results indicate that EP/AgNPs have good antidiabetic activity and therefore could be used to prevent the development of diabetes. The biosynthesized AgNPs from bark methanol/water extract of E. polystachya contain bioactive compounds such as chalcones, flavonoids, and dihydrochalcones, which play a determinant role in the phytofabrication of the AgNPs. EP/AgNPs promote pancreatic β-cell survival, insulin secretion-enhanced hyperglycemia, and hyperlipidemia in glucose-induced diabetic zebrafish. In addition, EP/AgNPs restore insulin secretion from INS-1 cells stimulated by H2O2, suggesting that this could result from cytoprotection against oxidative injury. These findings suggest that EP/AgNPs could be used as therapeutic nanoparticles to prevent the development of diabetes.
Palo Azul has been reported to exhibit many physiological effects that contribute to the prevention of metabolic syndromes, although its mechanism is unclear. Among Palo Azul’s various activities, we investigated the hypothesis that palo promotes adipocytes differentiation and regulates adipokine profiles in 3T3-L1 adipocytes by modulation of peroxisome proliferator-activated receptor (PPAR) γ, a major regulator of adipose differentiation.
Conclusion: Real-time polymerase chain reaction and luciferase reporter assay showed that Palo Azul up-regulated expression and transcriptional activity of PPARγ. Furthermore, Palo Azul increased the expression of insulin-sensitizing adipokine, adiponectin, which is a directly target of PPARγ, both at the messenger RNA level and at the protein level. In summary, Palo Azul demonstrated the potential to improve insulin resistance by promoting adipocyte differentiation via PPARγ activation. Results suggest an increase in adiponectin secretion and a decrease in insulin-resistant factors such as leptin and resistin.
Hiromi Sato, Asami Funaki, Yuki Kimura, Mai Sumitomo, Hiroya Yoshida, Hideki Fukata, Koichi Ueno
In this study, we examined the cell differentiation effect of an ethanol extract of Cyclolepis genistoides D. Don, a herbaceous perennial belonging to the family Asteraceae (vernacular name: palo azul). Palo Azul has numerous physiological effects that contribute to the prevention of metabolic syndromes, although the mechanism remains unclear. We previously suggested that Palo Azul has antidiabetic activity via an adipose differentiation effect.
In conclusion, Palo Azul may increase muscle mass in the body and improve insulin resistance conditions by facilitating the formation of myotubes by promoting myocyte differentiation.
Eysenhardtia polystachya is widely used in folk medicine as an anti-rheumatic and analgesic agent, but no systematic study of its effects on several markers associated with rheumatoid arthritis and its ethnomedical use as analgesic agent has been performed. We evaluated the anti-arthritic and antinociceptive properties of an ethanolic extract of E. polystachya (EE) bark and its rich-flavonoids fractions in murine models. Many plant constituents, including flavonoids, have proven effective against arthritis by reducing cartilage degradation, diminishing leukocyte infiltration in the synovial space, decreasing serum cytokine levels, and other mechanisms (9). Phytochemical studies indicate that E. polystachya contains polyphenols, and previous chemical examination of this species led to the isolation and structural elucidation of several flavonoids (11, 12). The methanol-water extract showed antidiabetic and anti-hyperlipidemic activities, an ability to reduce the formation of advanced glycation end products, and an antioxidant capacity in-vitro (12).
Conclusion: EE and its rich-flavonoids fractions inhibited secondary inflammatory reactions, diminished the specific histopathological alterations in the joint capsule and reduced the serum concentrations of the pro-inflammatory cytokines IL-6, TNF-α, and GM-CSF in arthritic rats. EE also reduced the number of writhes produced by acetic acid and increased the response time on the hot plate for mice. Our findings support the use of Eysenhardtia polystachya bark for the treatment of rheumatoid arthritis and pain management.
In conclusion, the ethanolic extract of Eysenhardtia polystachya bark and its rich-flavonoids fractions inhibited secondary inflammatory reactions in arthritic rats and delayed histopathological alterations of joint capsules. Eysenhardtia polystachya also decreased the serum levels of pro-inflammatory cytokines IL-6, TNF-α, and GM-CSF and showed antinociceptive activity at the peripheral and central levels, which suggests that this plant has an effect on the cellular immune response. These findings support the use of Eysenhardtia polystachya in Mexican folk medicine for treating rheumatoid arthritis and pain management.
The methanolic extracts from branches (BEP) and leaves (LEP) of Eysenhardtia platycarpa significantly decreased the blood glucose levels in normal and streptozotocin (STZ)-induced diabetic rats. 3-O-Acetyloleanolic acid (7), identified as the major constituent of BEP, showed a significant decrease (31 mg/kg of body weight, P < 0.05) in the glucose level of STZ induced diabetic rats. The obtained results correlate with the traditional use of this species.
Because of the high reactivity of the hydroxyl group, flavonoids (Fl-OH) are able to reduce highly oxidizing free radicals with redox potentials by hydrogen atom donation, according to Eq. (10), where R• represents superoxide anion, peroxyl, alkoxyl, and hydroxyl radicals.
Flavonoids are important phytochemical components of wheat bran, and have been shown to be potent antioxidants with anticancer activity.81,82 In addition, flavonoids have a role in the treatment of diabetes83,84 by virtue of their ability to protect against hyperglycemic and alloxan-induced oxidative stress in experimental animal models.85 In a large cohort of women, a clinical trial has shown that flavonoids are protective against type 2 diabetes.
These components of wheat bran possess health benefits for humans, including preventative effects against cancer and type 2 diabetes. Various studies have reported that these compounds exhibit significant antioxidant capabilities, including scavenging free radicals, chelating metal ions, and activating antioxidant enzymes, suggesting antioxidant properties of wheat bran. This chapter includes an overview of stress and oxidative stress and a discussion of the antioxidant properties of wheat bran.
Results from both cohort studies and randomized trials suggest that anthocyanidins from berries and flavan-3-ols from green tea and cocoa may lower the risk of type 2 diabetes and cardiovascular diseases. Meta-analyses of randomized trials indicate that the strongest evidence exists for a beneficial effect of green tea on LDL-cholesterol and a beneficial effect of flavan-3-ol-rich cocoa on endothelial function and insulin sensitivity.
Evidence from cohort studies and randomized trials suggest beneficial effects of food sources of anthocyanidins (berries) and flavan-3-ols (green tea and cocoa) on cardiovascular health.