Palo Azul & Flavonoids Vs. Coronavirus
¿Are you boosting your immune system to protect against Coronavirus (COVID-19?)?
How can palo azul protect against Coronavirus? The answer is simple. Flavonoids.
In case you haven’t heard of flavonoids before, this study published in April 2020 mentioned the following:
“Flavonoids are secondary metabolites produced by plants and play very important roles in plant physiology, possessing a variety of potential biological benefits such as antioxidant, anti- inflammatory, anticancer, antibacterial, antifungal and antiviral activities [5, 6].”
There’s a ton of studies about flavonoids (contained in palo azul) and they’ve found numerous health benefits.
The way the Coronaviruses attack our bodies is that they use the DNA in our cells to send out RNA signals that replicate the virus. This is why it is very important to raise the body's defenses to prevent the initial replication from taking place.
A recent study which was published in Feb 2020 found the following:
“Flavonoids from plants serve as a vast reservoir of therapeutically active constituents that have been explored as potential antiviral candidates against RNA and DNA viruses.” RNA and DNA viruses (such as COVID-19) attach to our own cells and send RNA signals through our cell membranes to replicate themselves.
In other words, RNA and DNA viruses use our own cells to multiply themselves and attack our bodies.
These are some of the MOST flavonoid-rich foods: apples, pears, onions, strawberries, blueberries, celery, peppers, and teas such as palo azul
This same study found that “flavonoids block attachment and entry of viruses into cells, interfere with various stages of viral replication processes or translation and polyprotein processing to prevent the release of the viruses to infect other cells.”
The researchers from this study also mentioned that "a flavonoid derivative was found to interfere with the entry of severe acute respiratory syndrome coronavirus (SARS-CoV) by interacting with the S2 protein of SARS-CoV viruses.”
Lastly, the scientists reported that “another flavonoid derivative, kaempferol, also inhibited coronavirus channel 3a and blocked the release of the virus' progeny.”
FOX News Article
FOX News published an article on April 6, 2020 regarding some information of great importance regarding COVID-19. The article is titled “Doctor Offers Coronavirus Protection Advice” and they feature advice from Leo Galland M.D., who is an internist and has published several medical books.
This is what Dr. Leo Galland had to say about coronavirus protection:
NUTRITIONAL STRATEGIES FOR CONFRONTING THE CHALLENGE OF COVID-19
“Consume flavonoids and other plant-based polyphenols for 2 purposes. Support ACE-2 activity and build up cellular levels to inhibit the action of 2 critical protease enzymes (Furin and 3CL-protease).”
In case you don’t know what flavonoids and polyphenols are….they are natural compounds with many beneficial health properties and they are found in vegetables, fruits, plants, and teas such as palo azul.
An extremely important point that Dr. Galland mentioned is that “corona viruses produce damage and spread to other cells by creating an enzyme called 3CL protease.”
He also mentions that “3CL protease is the most important for the corona virus family. It has been called “the Achilles heel” of corona virus and is the subject of new anti-viral drug development.”
More importantly though, he suggests that “dietary flavonoids inhibit 3CL protease in laboratory studies and for that reason may limit severity of infection.”
* Here’s a very important fact!
Dr. Galland mentions that “quercetin (flavonoid) is presently being studied in China as a drug treatment for COVID-19, based on research initiated at McGill University.”
Not only do flavonoids inhibit 3CL protease, they also enhance an enzyme called ACE-2 which “scientists believe to be responsible for the severity of pneumonia and for catastrophic effects like heart failure, blood clots and circulatory collapse.” In fact, Dr. Galland said the following:
“I believe that all the clinical manifestations of COVID-19 can be traced to ACE-2 destruction by the virus.”
Moreover, “laboratory studies have shown that restoring ACE-2 dramatically reduces the severity of pneumonia in animals with many types of lung injury, infectious or toxic, including those infected with SARS CoV-1, a close relative of SARS-CoV-2.”
Natural substances shown to enhance ACE-2 function include curcumin, rosmarinic acid and resveratrol...all of which are flavonoid derivatives.
** But that’s not all! According to Dr. Galland, flavonoids such as resveratrol “have a number of beneficial effects on corona virus infection beyond ACE-2 support; it inhibits the growth of the deadly MERS corona virus by multiple mechanisms. In addition, resveratrol diminishes the kind of inflammation associated with corona virus infection.”
Dr. Galland mentions that “If you are exposed, there are measures you can take, based on the biology of the virus, which may diminish the likelihood of severe illness. These are not treatments for disease; they are preventive strategies to help place you among the 80% with mild to minimal illness and they have the greatest chance of succeeding if they are implemented before you are exposed.”
In conclusion, Dr. Galland mentions that “the lung damage of advanced corona virus pneumonia is due to an overactive immune response, so some immune boosting therapies should be used only for prevention or early infection and not for severe illness. Fortunately, flavonoids decrease inflammation and specifically down-regulate the NLRP3 inflammasome.”
As if all this wasn’t enough information...we felt that we had to share this upcoming study with you because it found some extremely important results about flavonoids and their potential for inhibiting COVID-19!
Targeting SARS CoV-2 Spike Protein of COVID-19 with Naturally Occurring Phytochemicals
This study was published even more recently in April 9, 2020 starts by saying that since ancient times, we have relied on naturally occurring phytochemicals such as flavonoids to fight diseases and infection.
For this study, the researchers analyzed the affinity of 10 potential naturally occurring flavonoids/non-flavonoids against the SARS-CoV-2 spike protein and compared their affinity with the FDA approved drug hydroxychloroquine (HCQ).
What is hydroxychloroquine (HCQ)? Hydroxychloroquine is a drug used to prevent and treat malaria. It is currently being studied as the potential treatment for COVID-19 and was approved by the FDA as an emergency treatment for treating Coronavirus.
This is why the next finding is so important. They found that flavonoids have “significantly high binding affinity for the two main important domains of the spike protein” of COVID-19. Moreover, “their binding affinities are much higher compared to that of HCQ.”
Essentially, the researchers are saying that flavonoids could be more effective as a potential treatment for COVID-19 than hydroxychloroquine, which is the current potential candidate!
The researchers go on to mention that “different flavonoids including both flavones and flavonols have been quite thoroughly investigated for their potential antiviral properties and many of them showed significant antiviral response in both in vitro as well as in vivo studies .”
They found that “about 10 of these compounds effectively binds to the C-terminal region of either the S1 domain or the S2 domain of SARS-CoV-2S and their binding interaction are more stable than with that of HCQ (hydroxychloroquine).”
As the scientists conclude their study, they affirm that “herbal medicines formulated from the phytochemicals we predicted, will be extremely essential for the treatment of SARS-CoV-2 infections.”
Lastly, they conclude with the following statement:
“Our findings suggest that all of these compounds have the potential to inhibit SARS- CoV-2 and should be explored further as preventive therapeutics for COVID-19.”
In this same study, the scientists outline several different flavonoid derivatives and their specific anti-viral properties that have been found in medical studies.
“Resveratrol has been found to exhibit anti-viral activities against a wide range of viruses including HIV-1 , pseudorabies virus (PVR), Middle East Respiratory Syndrome coronavirus (MERS-CoV) and also reduced the expression of MERS- CoV nucleocapsid (N) protein [14-17].”
“Pterostilbene, which is chemically similar to resveratrol, is found in berries and grapes and has been found to inhibit the replication of several viruses, including herpes simplex viruses (HSVs) 1 and 2, varicella-zoster virus, influenza virus and human papillomaviruses.”
“Quercetin has demonstrated antiviral activity against respiratory syncytial virus, poliovirus type 1, HSV-1, HSV-2, Ebola virus infection .”
“Apigenin has shown potent antiviral activity against hepatitis B virus, adenoviruses, african swine fever virus and some RNA viruses in vitro .”
“Luteolin, another acclaimed flavone has shown significant antiviral effects on both HIV-1 reactivation, inhibition of Epstein-Barr virus (EBV),Chikungunya virus, Japanese encephalitis virus , severe acute respiratory syndrome coronavirus (SARS-CoV) and rhesus rotavirus.”
“Curcumin, a component of turmeric, has exhibited enhanced antiviral activity against diverse viruses such asdengue virus (serotype 2) herpes simplex virus, human immunodeficiency virus (HIV), Zika and chikungunya viruses among others.”
“Kaempferol, another flavonol, has shown inhibitory activity against HCMV, HSV-1, HSV-2 and influenza A virus .”
“Fisetin, a modified flavonol has shown to inhibit CHIKV infection as well as the HIV-1 infection by blocking viral entry and virus-cell fusion .”
In conclusion, flavonoids are effective anti-virals and have shown potential in inhibiting Coronaviruses...but as of April 16, 2020, there is no approved treatment for COVID-19.
Whether flavonoids contribute to the prevention of COVID-19 is yet to be determined, but based on Dr. Galland’s recommendations and these medical studies, they are effective at boosting your immune system and inhibiting attachment of the coronavirus.
In summary...there is no reason why you shouldn't raise your defenses against coronavirus by consuming foods rich in flavonoids such as celery, onions, strawberries, blueberries, apples, turmeric and palo azul tea!